Abstract: Commensal microorganisms predominantly reside inside or on the human body. These organisms are collectively called the microbiome. The human intestinal tract harbors the most abundant and diverse collection of microbes. Probiotic products or supplements have been linked to particular health concerns. These products contain probiotic strains that exhibit beneficial characteristics tailored to address specific clinical conditions, primarily related to the gastrointestinal tract. Within these, the dysregulation of gut microbiota may contribute to the occurrence or development of Alzheimer’s disease and Parkinson’s disease through diverse mechanisms that are not yet fully understood but are believed to involve modulations in gut microbiome composition, strengthening of gut barrier integrity, and interactions with the host’s immune system. Although the effectiveness of probiotics can vary depending on various factors and the process of choosing appropriate probiotic formulations through diverse strains with optimal effectiveness can be challenging, understanding the fundamental mechanisms and assessing the effectiveness of probiotics have the potential to provide potential treatment options for neurodegenerative diseases. Here we aimed to review the possible interaction between probiotics and neurological diseases.
Cite this article as: Zarei G, Norizadeh M, The potential impact of probiotics on neurodegenerative diseases. Trends Pharm. 1, 12, doi: 10.5152/TrendsPharm.2024.24012.